Rene Descartes, in his Meditations on First Philosophy, addresses a wide variety of questions, from nature of the self and perception, to the demonstration of the existence of the world and of God. However, his argument in these Meditations begins at a point of radical scepticism concerning the existence of the universe and the nature of reality. Central to this argument is the idea of Cartesian dualism, or the separation of rational intellect from the body and the senses. In this context, this paper will argue, through a examination of various facets of Descartes' argument, that in the final analysis Meditations on First Philosophy retains a measure of this scepticism in its refusal to accept the position that knowledge may be acquired by the senses. 4 pgs. Bibliography lists 1 source.